Stuart Isaac was 48-years-old at the time of his disappearance. He drove approximately 32 hours from his home in Burtonsville, Maryland to Yellowstone National Park, and has been missing since September 26, 2010.

Somewhere en route to the national park on September 24, 2010 at 3:30a, he placed a call to a high-school friend, Matsue Evans, whom he spoke to for at least 2 hours. Matsue mentioned how she was surprised to receive a phone call from Isaac as they normally communicated through text messages, or emails.

On September 26, 2010, Isaac's black 2009 Lexus IS-250 sedan was located at Craig Pass in Yellow Stone National Park, off Grand Loop Rd in Wyoming. Soon after locating Isaac's vehicle, search teams used both ground and air search-tactics, but no signs of Isaac, nor any signs of human remains, were spotted.

Stuart Isaac was not an experienced outdoorsmen, and his reason for visiting Yellowstone National Park are not known.